尹恒
出生年月：1982.10
工作单位：中国科学院大连化学物理研究所
职称/职务：研究员/研究组组长
地址：大连化物所1805组，辽宁省大连市中山路457号，116023
电话：0411-84379061；邮箱：yinheng@dicp.ac.cn
个人简介
尹恒，研究员，博导，国家“高层次人才特殊支持计划”科技创新领军人才，中科院特聘研究员“核心岗位”、中科院青年创新促进会优秀会员、大连化物所首席研究员。现任天然产物及糖工程研究组组长，辽宁省碳水化合物研究重点实验室主任，大连市糖类农用制剂工程研究中心主任。
1982年10月生，2003年毕业于大连理工大学精细化工专业获学士学位；2008年毕业于中科院大连化物所生物化工专业获博士学位，期间于2004-2006年在复旦大学糖复合物卫生部重点实验室进行联合培养。毕业后留所工作至今，其间于2010-2011年在丹麦奥胡斯大学做访问学者。2011年任副研究员，2015年任研究员。
研究方向主要为糖工程及酶工程、糖生物学及植物免疫。在糖工程领域，致力于将天然碳水化合物资源转化为功能产品或能源产品，重点研究如何绿色高效的从多糖降解制备得到寡糖，并对此过程中重要的生物酶进行创制及机制研究。开发得到海藻酸钠裂解酶、葡聚糖酶等多种新型多糖降解酶，这些酶除应用于功能寡糖生产外，已与知名酶制剂公司合作开发产品，进入市场。通过酶法制备得到海藻酸钠寡糖等系列寡糖，通过和企业合作，开发生物农药、肥料多种获农药登记证等国家相关证书，在全国多地多种作物上实现了寡糖农用制剂大规模推广应用，产生较大社会与经济效益；相关产品已在东南亚一带一路国家及美国投入应用。在糖生物学领域，主要研究植物中糖基化修饰等基础糖生物学问题，解析植物体内重要单糖的合成途径并明确途径中关键酶的功能；研究外源寡糖在植物上调节植物免疫作用的功能、机制与应用，系统研究了寡糖激活植物免疫诱导植物抗病的作用机制。
累计主持“一带一路”科学联盟合作专项、国家重点研发计划课题、国家自然科学基金、中科院STS、企业横向等30余项课题。主编外文专著一部，参与编著中文著作四部，发表SCI论文百余篇（其中中科院一区50余篇），授权专利40余项，已实现转化应用10余项。担任科技部“生物农药与生物防治产业技术创新战略联盟”副理事长、全国农药标委会生物农药分委会委员、中国生物工程学会糖生物工程专委会委员、中国生化与分子生物学会糖复合物专委会委员、中国生物物理学会糖生物学专委会委员、中国植物保护学会生物防治专委会委员等学术兼职。入选中科院青促会优秀会员、辽宁省百千万人才百层次、兴辽英才、大连市杰出青年科技人才等人才项目；获得海洋科学技术奖一等奖、辽宁省科技进步二等奖、张树政糖科学奖优秀青年奖等科技奖励。
研究工作经历
2015/07-，中科院大连化物所，研究员、研究组组长;
2015/05-2015/07，中科院大连化物所，副研究员、研究组组长;
2013/05-2015/05，中科院大连化物所，副研究员、研究组召集人;
2012/01-2013/05，中科院大连化学物理研究所生物技术部，副研究员、研究组组副组长
2011/10-2012/01，中国科学院大连化学物理研究所，生物技术部，副研究员
2008/09-2011/10，中国科学院大连化学物理研究所，生物技术部，助研，其中：
2010/03-2011/02，丹麦奥胡斯大学，食品科学系，公派访问学者
受教育经历
2003/09-2008/08，中国科学院大连化学物理研究所，生物化工，硕博连读，其中：
2003/09-2004/09, 中国科学院研究生院基础课学习
2004/12-2006/08, 复旦大学上海医学院基因中心联合培养
1999/09-2003/06，大连理工大学，化工学院，学士
Journal papers (In recent 5 years)
1. Hongguo Xie, Guanglu Yu, Xueran Wang, Deyu Chu, Chao Song, Pei Wang, Kuai Dai, Jiangzhou Li, Heng Yin. Sea urchin-like nanocarrier for enhancing pesticide retention and rain fastness on hydrophobic and hydrophilic crop foliage, Chemical Engineering Journal, 2024, 490, 151901.
2. Hui Gu, Jin Qin, Jinxuan Wen, Yudie Lin, Xiaochen Jia, Wenxia Wang, Heng Yin. Unveiling the structural properties and induced resistance activity in rice of Chitin/Chitosan-Glucan Complex of Rhizoctonia solani AG1 IA inner cell wall. Carbohydrate Polymers, 2024, 337, 122149.
3. Wa Gao, Tang Li, Haichuan Zhou, Jiu Ju, Heng Yin. Carbohydrate-binding modules enhance H2O2 tolerance bypromoting lytic polysaccharide monooxygenase active siteH2O2 consumption.Journal of Biological Chemistry, 2024, 300(1): 105573.
4. Yu Xiao, Guangzheng Sun, Qiangsheng Yu, Teng Gao, Qinsheng Zhu, Rui Wang, Shijia Huang, Zhifu Han, Felice Cervone, Heng Yin, Tiancong Qi, Yuanchao Wang, Jijie Chai. A plant mechanism of hijacking pathogen virulence factors to trigger innate immunity.Science, 2024, 383(6684): 732-739.
5. Xiaochen Jia, Hongyan Zhang, Hongqiang Qin, Kuikui Li, Xiaoyan Liu, Wenxia Wang, Mingliang Ye,Heng Yin. Protein O-GlcNAcylation impairment caused by N-acetylglucosamine phosphate mutase deficiency leads to growth variations in Arabidopsis thaliana.The Plant Journal, 2023, 114(3):613-635.
6. YudieLin, Hui Gu, Xiaochen Jia, Wenxia Wang, Bo Hong, Fuyun Zhang, Heng Yin. Rhizoctoniasolani AG1 IA extracellular polysaccharides: Structural characterization and induced resistance to rice sheath blight. International Journal of Biological Macromolecules, 2023, 244, 125281.
7. Lilin Song, Mengru Sun, Jinhui Shi, Zhenhao Tian, Yuqing Song, Huixin Liu, Shanshan Zhao,Heng Yin, Guangbo Ge. Rational Construction of a Novel Bioluminescent Substrate for Sensing the Tumor-Associated Hydrolase Notum. Analytical Chemistry, 2023, 95, 5489-5493.
8. Yu Wang, Peiyu Xu, Wenxia Wang, Xiaochen Jia, Liping Zhu, Heng Yin. Oligosaccharides increased both leaf biomass and steviol glycosides content ofSteviarebaudiana. Plant Physiology and Biochemistry, 2023, 202, 107937.
9. XiaohuiSong, TangLi, HuiGu, HengYin. Space exposure enhanced pectin-degrading enzymes expression and activity in Aspergilluscostaricaensis. World Journal of Microbiology and Biotechnology,2023, 39, (11), 295.
10. Changzheng Chen, Kuikui Li, Tang Li, Junyan L, Qishun Liu, Heng Yin. Identification and Characterization of a Novel Mannanase from Klebsiellagrimontii. Bioengineering, 2023, 10, (10).
11. Tang Li, Xiaohui Song, Preyesh Stephen, Heng Yin, Sheng-Xiang Lin. New insights into the substrate inhibition of human 17beta-hydroxysteroid dehydrogenase type 1. Journal of Steroid Biochemistry and Molecular Biology, 2023, 228, (106246), 1-10.
12. Zhongbin Xiao, Kuikui Li, Tang Li, Fanxing Zhang, JiayiXue, Miao Zhao, Heng Yin. Characterization and Mechanism Study of a Novel PL7 Family Exolytic Alginate Lyase from Marine Bacteria Vibrio sp. W13. Applied Biochemistry and Biotechnology, 2023.
13. Xueran Wan, Hongguo Xie, Pei Wang and Heng Yin. Nanoparticles in Plants: Uptake, Transport and Physiological Activity in Leaf and Root. Materials, 2023, 16, 3097.
14. Rongyue Wang, Xiaofan Li, Jinwei Tang, Juan Liu, Heng Yin, Ruijun Li, Shigen Ye. Dietary effect chitosan nanoparticles on growth performance, immunity and resistance against Vibrio splendidus in the sea cucumber Apostichopus japonicas. Aquaculture Reports, 30 (2023) 101625.
15. Wa Gao, Heng Yin. Insight into the peroxygenase activity of lytic polysaccharide monooxygenases (LPMO): Recent progress and mechanistic understanding. Chemical Physics Reviews, 2023, 4, (031310).
16. Yijie Dong, Tang Li, Shiqing Zhang, Joaquin Sanchis, Heng Yin, Jie Ren, Xiang Sheng, Guangyue Li, Manfred T. Reetz. Biocatalytic baeyer-villiger reactions: Uncovering the source of regioselectivity at each evolutionary stage of a mutant with scrutiny of fleeting chiral intermediates. ACS Catalysis, 2022, 12(6): 3669-3680.
17. Lingfeng Long, Yun Hu, Fubao Sun, Wa Gao, Zhikui Hao, Heng Yin. Advances in lytic polysaccharide monooxygenases with the cellulose-degrading auxiliary activity family 9 to facilitate cellulose degradation for biorefinery. International Journal of Biological Macromolecules, 2022, 219: 68-83.
18. En Yu, Daiwen Chen, Bing Yu, Zhiqing Huang, Xiangbing Mao, Ping Zheng, Yuheng Luo, Heng Yin, Jie Yu, Junqiu Luo, Hui Yan, Jun He. Alteration of porcine intestinal microbiota in response to dietary manno-oligosaccharide supplementation. Frontiers in Microbiology, 2022, 12: 811272(1-11).
19. Wa Gao, Hefeng Zhang, Tang Li, Jiu Ju, Haichuan Zhou, Xu Zong, Heng Yin. Controlled depolymerization of cellulose by photoelectrochemical bioreactor using a lytic polysaccharide monooxygenase. Biochemical Engineering Journal, 2022, 187: 108597(1-6).
20. Can Zhao, Chunyan Wu, Kuikui Li, John F. Kennedy, Michael Wisniewski, Lihong Gao，Chenggui Han, Jia Liu, Heng Yin, Xuehong Wu. Effect of oligogalacturonides on seed germination and disease resistance of sugar beet seedling and root. Journal of Fungi, 2022, 8(716): 1-13.
21. Ruixin Li, Maolong Li, Jinxia He, Hongguo Xie, Wenxia Wang, Meng Zhang, Gustavo Cabrera-Barjas, Pierfrancesco Morganti, Heng Yin. Preparation of pectin nanospheres and its effect on wheat (Triticum aestivum L.) seed germination and growth. Journal of Plant Growth Regulation, 2022. 41: 3197-3207.
22. Xiao Yin, HongguoXie, Ruixin Li, Shenggang Yan, Heng Yin. Regulating association strength between quaternary ammonium chitosan and sodium alginate via hydration. Carbohydrate Polymers. 2021, 255: 117390(1-8).
23. Jin Wan, Jiao Zhang, Qingsong Xu, Heng Yin, Daiwen Chen, Bing Yu, Jun He. Alginate oligosaccharide protects against enterotoxigenic Escherichia coli-induced porcine intestinal barrier injury. Carbohydrate Polymers. 2021, 270: 118316(1-12).
24. Tang Li, Ningning Zhang, Shenggang Yan, Shan Jiang, Heng Yin. A novel tyrosinase from armillariaostoyae with comparable monophenolase and diphenolase activities suffers substrate inhibition. Applied and Environmental Microbiology. 2021, 87(12): 1-14.
25. Guojun Yang, Shuguang Li, Haidong Tan, Kuikui Li, Wei Chen, Heng Yin. A highly efficient biocatalytic conversion of renewable pectic polysaccharide biomass into bioactive oligogalacturonides. ACS Food Science & Technology. 2021, 1(3): 338-346.
26. Yu Wang, Xue Sun, XiaochenJia, Liping Zhu, Heng Yin. Comparative transcriptomic of Stevia rebaudiana provides insight into rebaudioside D and rebaudioside M biosynthesis. Plant Physiology and Biochemistry. 2021, 167: 541-549.
27. Santosh Kumar Bose, Yanqiu He, Prianka Howlader, Wenxia Wang, Heng Yin. The N-glycan processing enzymes beta-D-N-acetylhexosaminidase are involved in ripening-associated softening in strawberry fruit. Journal of Food Science and Technology. 2021, 58: 621-631.
28. Qian Li, Chaofeng Jiang, Haidong Tan, Xiaoming Zhao, Kuikui Li, Heng Yin. Characterization of recombinant E. coli expressing a novel fucosidase from Bacillus cereus 2-8 belonging to GH95 family. Protein Expression and Purification. 2021, 105897: 1-7.
29. En Yu, Daiwen Chen, Bing Yu, Yuheng Luo, Ping Zheng, Heng Yin, Xiangbing Mao, Zhiqing Huang, Jie Yu, Junqiu Luo, HuiYan, Jun He. Amelioration of enterotoxigenic Escherichia coli-induced disruption of intestinal epithelium by manno-oligosaccharide in weaned pigs. Journal of Functional Foods. 2021, 82: 104492(1-10).
30. Gustavo Cabrera-Barjas, Cristian González, Aleksandra Nesic, Kelly P. Marrugo, Oscar Gómez, Cédric Delattre, Oscar Valdes, Heng Yin, Gaston Bravo, Juan Cea. Utilization of marine waste to obtain β-chitin nanofibers and films from giant humboldt squid Dosidicus gigas. Marine Drugs. 2021, 19(4): 184.
31. En Yu, Daiwen Chen, Bing Yu, Zhiqing Huang, Xiangbing Mao, Ping Zheng, Yuheng Luo, Heng Yin, Jie Yu, Junqiu Luo, Hui Yan, Jun He. Manno-oligosaccharide attenuates inflammation and intestinal epithelium injury in weaned pigs upon enterotoxigenic Escherichia coli K88 challenge. British Journal of Nutrition. 2021, 126(7): 993-1002.
32. Hefeng Zhang, Yong Zhao, Huiyan Zhang, Haichuan Zhou, Hong Wang, Xu Zong, Heng Yin, Can Li. Establishing inorganic-biological hybrid photoelectrochemical platform towards sustainable conversion of α-chitin. Applied Catalysis B: Environmental. 2020, 265: 118558.
33. Guojun Yang, Haidong Tan, Shuguang Li, Meng Zhang, Jia Che, Kuikui Li, Wei Chen, Heng Yin. Application of engineered yeast strain fermentation for oligogalacturonides production from pectin-rich waste biomass.Bioresource Technology. 2020, 300: 122645.
34. Xiaochen Jia, Haihong Zeng, Santosh Kumar Bose, Wenxia Wang, Heng Yin.Chitosan oligosaccharide induces resistance to Pst DC3000 in Arabidopsis via a non-canonical N-glycosylation regulation pattern.Carbohydrate Polymers. 2020, 250: 116939.
35. Haichuan Zhou, Yuebin Zhang, Tang Li, Haidong Tan, Guohui Li, Heng Yin. Distinct Interaction of Lytic Polysaccharide Monooxygenase with Cellulose Revealed by Computational and Biochemical Studies. Journal of Physical Chemistry Letters. 2020,11: 3987-3992.
36. Jia Liu, John F. Kennedy, Xiaofang Zhang, Heng Yin, Wei Chen, Zhuo Chen, Xian Wu, Xuehong Wu. Preparation of alginate oligosaccharide and its effects on decay control and quality maintenance of harvested kiwifruit. Carbohydrate Polymers. 2020,242: 116462.
37. Santosh Kumar Bose, Prianka Howlader, Wenxia Wang, Heng Yin. Oligosaccharide is a promising natural preservative for improving postharvest preservation of fruit: A review. Food Chemistry. 2020, 341: 128178.
38. Ruixin Li, Hongguo Xie, Chunguang Zhang, Yeqing Sun, Heng Yin. ROS-Responsive Polymeric Micelle for Improving Pesticides Efficiency and Intelligent Release. Journal of Agricultural and Food Chemistry.2020, 68: 9052-9060.
39. Guojun Yang, Wei Chen, Haidong Tan, Kuikui Li, Junyan Li, Heng Yin. Biochemical characterization and evolutionary analysis of a novel pectate lyase from Aspergillus parasiticus. International Journal of Biological Macromolecules. 2020, 152: 180-188.
40. Junjie Liu, Chunguang Zhang, Xiaochen Jia, Wenxia Wang, Heng Yin. Comparative analysis of RNA-binding proteomes under Arabidopsis thaliana-Pst DC3000-PAMP interaction by orthogonal organic phase separation. International Journal of Biological Macromolecules. 2020, 160: 47-54.
41. Prianka Howlader, Santosh Kumar Bose, Xiaochen Jia, Chunlai Zhang, Wenxia Wang, Heng Yin. Oligogalacturonides induce resistance in Arabidopsis thaliana by triggering salicylic acid and jasmonic acid pathways against Pst DC3000.International Journal of Biological Macromolecules. 2020, 164: 4054-4064.
42. Ming Sun, Chu Sun, Tang Li, Kuikui Li, Shenggang Yan, Heng Yin. Characterization of a novel bifunctional mannuronan C-5 epimerase and alginate lyase from Pseudomonas mendocina. sp. DICP-70.International Journal of Biological Macromolecules. 2020, 150: 662–670.
43. Junyan Ma, Tang Li, Haidong Tan, Wujun Liu, Heng Yin. The important roles played insubstrate binding of aromatic aminoacids in exo-inulinase fromKluyveromyces cicerisporusCBS 4857.Frontiers in Molecular Biosciences. 2020,7: 569797.
44. Fu Hu, Benwei Zhu, Qian Li, Heng Yin, Yun Sun, Zhong Yao, Dengming Ming. Elucidation of a unique pattern and the role of carbohydrate binding module of an alginate lyase. Marine Drugs. 2020, 18, 32.
45. Xiaochen Jia, Hongqiang Qin, Santosh Kumar Bose, Tongmei Liu, Jinxia He, Shangqiang Xie, Mingliang Ye, Heng Yin. Proteomics analysis reveals the defense priming effect of chitosan oligosaccharides in Arabidopsis-Pst DC3000 interaction. Plant Physiology and Biochemistry. 2020, 149: 301-312.
46. Kuikui Li, Huan Qi, Qishun Liu, Tang Li, Wei Chen, Shuguang Li, Hai-long Piao, Heng Yin. Preparation and antitumor activity of selenium-modified glucomannan oligosaccharides. Journal of Functional Foods.2020, 65: 103731.
47. Shuli Wu, Qishun Liu, Haidong Tan, Fuyun Zhang, Heng Yin. A novel 2,5-furandicarboxylic acid biosynthesis route from biomass-derived 5-hydroxymethylfurfural based on the consecutive enzyme reactions. Applied Biochemistry and Biotechnology. 2020, 191: 1470-1482.
48. Xiaochen Jia, Mijanur Rahman Rajib, Heng Yin. Recognition pattern, functional mechanism and application of chitin and chitosan oligosaccharides in sustainable agriculture. Current Pharmaceutical Design. 2020, 26: 1-14.
49. Chunguang Zhang, Wenxia Wang, Xiaoming Zhao, Hongying Wang, Heng Yin. Preparation of alginate oligosaccharides and their biological activities in plants: A review. Carbohydrate Research. 2020, 494: 108056.
50. Haidong Tan, Heng Yin. Optimization and characterization of oligosaccharides production from citrus peel waste resource using Aspergillus niger 1805. Journal of Microbiological Methods. 2020, 169: 105809.
51. Haidong Tan, Guojun Yang, Wei Chen, Qishun Liu, Kuikui Li, Heng Yin. Identification and characterization of thermostable endo-polygalacturonase II B from Aspergillus luchuensis.Journal of Food Biochemistry. 2020, 13133.
52. Prianka Howlader, Santosh Kumar Bose, Chunguang Zhang, Xiaochen Jia, Wenxia Wang, Heng Yin. Pectin oligosaccharide (POS) induce resistance in Arabidopsis thaliana through salicylic acid-mediated signaling pathway against Pseudomonas syringae pv.tomato DC3000.Physiological and Molecular Plant Pathology. 2020, 110: 101483.
53. Haidong Tan, Heng Yin. Optimization and characterization of oligosaccharides production from citrus peel waste resource using Aspergillus niger 1805. Journal Of Microbiological Methods. 2020, 169(105): 809.
54. Haidong Tan, Guojun Yang, Wei Chen, Qishun Liu, Kuikui Li, Heng Yin. Identification and characterization of thermostable endo‐polygalacturonase II B from Aspergillus luchuensis. Journal of Food Biochemistry. 2020, 44(3): e13133.
55. Chunguang Zhang, Prianka Howlader, Tongmei Liu, Xue Sun, Xiaochen Jia, Xiaoming Zhao, Peili Shen, Yimin Qin, Wenxia Wang, Heng Yin. Alginate Oligosaccharide (AOS) induced resistance to Pst DC3000 via salicylic acid-mediated signaling pathway in Arabidopsis thaliana. Carbohydrate Polymers. 2019, 225(115): 221.
56. Qishun Liu, Changhong Yao, Yongxin Sun, Wei Chen, Haidong Tan, Xupeng Cao, Song Xue, Heng Yin. Production and structural characterization of a new type of polysaccharide from nitrogen-limited Arthrospira platensis cultivated in outdoor industrial-scale open raceway ponds. Biotechnology For Biofuels. 2019, 12: 131.
57. Santosh kumar Bose, Prianka Howlader, Xiaochen Jia, Wenxia Wang, Heng Yin. Alginate oligosaccharide postharvest treatment preserve fruit quality and increase storage life via Abscisic acid signaling in strawberry. Food Chemistry. 2019, 283: 665-674.
58. Haichuan Zhou, Tang Li, Zuochen Yu, Jiu Ju, Huiyan Zhang, Haidong Tan, Kuikui Li, Heng Yin. A lytic polysaccharide monooxygenase from Myceliophthora thermophila and its synergism with cellobiohydrolases in cellulose hydrolysis. International Journal of Biological Macromolecules. 2019, 139: 570-576.
59. Benwei Zhu, Kuikui Li, Wenxia Wang, Limin Ning, Haidong Tan, Xiaoming Zhao, Heng Yin. Preparation of trisaccharides from alginate by a novel alginate lyase Alg7A from marine bacterium Vibrio sp. W13. International Journal of Biological Macromolecules. 2019, 139: 879-885.
60. Xian-yu Zhu, Yong Zhao, Huai-dong Zhang, Wen-xia Wang, Hai-hua Cong, Heng Yin. Characterization of the Specific Mode of Action of a Chitin Deacetylase and Separation of the Partially Acetylated Chitosan Oligosaccharides. Marine Drugs. 2019, 17: 74.
61. Junyan Ma, Qian Li, Haidong Tan, Hao Jiang, Kuikui Li, Lihua Zhang, Quan Shi, Heng Yin. Unique N-glycosylation of a recombinant exo-inulinase from Kluyveromyces cicerisporus and its effect on enzymatic activity and thermostability. Journal Of Biological Engineering. 2019, 13: 81.
62. Fengqin Gong, Qishun Liu, Haidong Tan, Tang Li, Chengyu Tan, Heng Yin. Cloning, expression and characterization of a novel (2R,3R) -2,3-butanediol dehydrogenase from Bacillus thuringiensis. Biotechnology, Biocatalysis and Agricultural. 2019, 22(101): 372.
63. Ming Sun, Chu Sun, Hongguo Xie, Shenggang Yan, Heng Yin. A simple method to calculate the degree of polymerization of alginate oligosaccharides and low molecular weight alginates. Carbohydrate Research. 2019, 486(107): 856.
1.辽宁省海洋经济发展项目“海洋多糖资源高值化利用关键技术研究及功能产品开发”，2022.4-2024.4；
2.“一带一路”国际科学组织联盟（ANSO）联合研究合作专项“新型糖类农用制剂在一带一路国家种植业的应用示范”，2021.6-2023.6；
3.大连市科技创新基金计划重点学科重大课题“糖类生物质利用”，2020.7-2023.6；
4. 国家自然科学基金面上项目“立枯丝核菌AA9家族裂解多糖单加氧酶在侵染水稻过程中的作用机制研究”，2023.01-2026.12 ；
5. 国家自然科学基金面上项目“拟南芥胞外含LysM结构域蛋白（AtLysMe）强化几丁寡糖信号识别的作用机制研究”，2020.1-2023.12；
6. 中国科学院青年创新促进会优秀会员，2020.1-2022.12；
7. 中国科学院重点部署项目课题“耐盐碱经济作物功能性食品研发与产业化示范”，2020.1-2021.6；
8. 国家自然科学基金面上项目“含CBM1结构域的多糖裂解单加氧酶鉴定及其底物结合机制研究”，2017.1-2020.12；
9. 国家重点研发计划课题“功能糖类免疫调控技术及产品开发”, 2017.07-2020.12；
10. 中国科学院科技服务网络计划“集成与示范绿色生物防控减肥减药技术”, 2018.08-2019.12。
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