教育背景

2001-2005 湘潭大学     生物工程         本科

2007-2010 中国农业科学院植物保护研究所     硕士

2013-2019 LavalUniversity 医学院        博士

工作背景

2010-2012 上海市计划生育科学研究所

研究方向

结构生物学，主要从事多糖降解相关的酶的结构解析及定向进化。

LiT, Stephen P, Lin SX. Crystal structures of human17β-hydroxysteroid dehydrogenase type 1 complexed with estrone and NADP+ revealthe mechanism of substrate inhibition. FEBS J. DOI: 10.1111/febs.14784.

Ran Q, Xiang Y, Stephen P, Wu C, Li T, Lin SX, Li Z. CRIF1–CDK2Interface Inhibitors: An Unprecedented Strategy for Modulation of CellRadiosensitivity. Journal of the American Chemical Society. 2019 Jan30;141(4):1420-1424.; DOI: 10.1021/jacs.8b10207.

LiT, Zhang W, Hao Jianhua, Sun M, Lin SX. Cold-active extracellularlipase: expression in Sf9 insect cells, homogenization and catalysis.Biotechnol Rep (Amst). 2018; 21:e00295. doi:10.1016/j.btre.2018.e00295.

LiT, Maltais R, Poirier D, Lin SX. Combined Biophysical ChemistryReveals a New Covalent Inhibitor with a Low-Reactivity Alkyl Halide. Journal ofPhysical Chemistry Letters. 2018; 9:5275-5280. doi:10.1021/acs.jpclett.8b02225.

LiT, Zhu DW, Labrie F, Lin SX. Crystal structures of human17β-hydroxysteroid dehydrogenase type 1 complexed with the dual-site inhibitorEM-139. Health. 2018; 10(8):1079-89. doi: 10.4236/health.2018.108081.

Wang XQ, Aka J, Li T, Xu D, Doillon C, Lin SX. Inhibition of 17beta-hydroxysteroiddehydrogenase type 7 modulates breast cancer protein profile and enhancesapoptosis by down-regulating GRP78. J Steroid Biochem Mol Biol. 2017 Jun 20;172:188-197. doi: 10.1016/j.jsbmb.2017.06.009.

He W, Gauri M, Li T, Wang R, Lin SX. Current knowledgeof the multifunctional 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1). Gene.2016; 588(1):54-61. doi: 10.1016/j.gene.2016.04.031.

Xing X, Liu Q, WangW, Zhang K, Li T et al. Shapeevolution with temperature of a thermo tolerant protein (PeaT1) in solutiondetected by small angle X-ray scattering. Proteins. 2013; 81:53–62.

Zhang SC, Sun M, Li T et al. Structure analysis of a newpsychrophilic marine protease. PLoS One. 2011; 6(11):e26939.

李唐, 曾洪梅, 邱德文. 激发素结构研究进展. 中国农业科技导报. 2010; 12(3):39-44. doi: 10.3969/j.issn.1008-0864.2010.03.07

刘权, 李唐, 曾洪梅, 杨秀芬, 邱德文. 通过园二色谱研究蛋白激发子PeaT1的耐热性.农业生物技术学报.2010; 18(3):592-596.